has material basis in germline mutation in WRN syndromic disease eye disorder autosomal recessive disease Werner syndrome https://github.com/monarch-initiative/mondo/issues/5682 https://github.com/monarch-initiative/mondo/issues/9285 https://www.malacards.org/card/werner_syndrome adult premature aging syndrome NANDO:2200831 adult progeria Orphanet:902 SCTID:51626007 Werner syndrome MONDO:0010196 WRN OMIM:277700 MEDGEN:12147 A rare inherited syndrome characterized by premature aging with onset in the third decade of life and with cardinal clinical features including bilateral cataracts, short stature, graying and thinning of scalp hair, characteristic skin disorders and premature onset of additional age-related disorders. UMLS:C0043119 GARD:0007885 Werner's syndrome MedDRA:10049429 ICD9:259.8 NANDO:1200676 NORD:1845 MESH:D014898 icd11.foundation:1864550134 DOID:5688 WS NCIT:C3447 progeroid syndrome hereditary poikiloderma