has material basis in germline mutation in disease arises from feature disease has basis in feature disease disrupts disease causes disruption of disease has feature F8 protein-glutamine gamma-glutamyltransferase activity Reduced factor VIII activity X-linked disease hemorrhagic disease hemophilia A https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/9097 https://www.malacards.org/card/factor_viii_deficiency https://www.malacards.org/card/hemophilia_a hemophilia type A MEDGEN:5501 HEMA factor VIII deficiency hemophilia A, congenital hereditary Factor VIII deficiency UMLS:C0019069 NORD:1221 icd11.foundation:337607970 MedDRA:10016080 MESH:D006467 hemophilia type a hereditary Factor VIII deficiency disease autosomal haemophilia a Haemophilia A SCTID:234440005 hem A MONDO:0010602 haemophilia type a NANDO:2200676 classic hemophilia OMIM:134500 classical hemophilia classical haemophilia congenital factor VIII disorder The most common form of hemophilia characterized by spontaneous or prolonged hemorrhages due to factor VIII deficiency. ICD10CM:D66 DOID:12134 Orphanet:98878 haemophilia a, X-linked recessive hemophilia A hemophilia a, X-linked recessive haemophilia type A classic haemophilia factor 8 deficiency NCIT:C27146 haemophilia A, congenital OMIM:306700 GARD:0006591 ICD9:286.0 hemophilia inherited blood coagulation disorder