has material basis in germline mutation in ZIC3 heterotaxy, visceral, 1, X-linked https://github.com/monarch-initiative/mondo/issues/4521 https://rarediseases.info.nih.gov/diseases/8591/x-linked-visceral-heterotaxy-1 https://www.malacards.org/card/heterotaxy_visceral_1_x_linked OMIM:306955 heterotaxy, visceral, 1, X-linked, X-linked recessive X-linked visceral heterotaxy 1 X-linked visceral heterotaxy type 1 is a very rare form of heterotaxy that has only been reported in a few families. Heterotaxy is the right/left transposition of thoracic and/or abdominal organs. This condition is caused by mutations in the ZIC3 gene, is inherited in an X-linked recessive fashion, and is usually seen in males. Physical features include heart abnormalities such as dextrocardia, transposition of great vessels, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis ; situs inversus, and missing (asplenia) and/or extra spleens (polysplenia).Affected individualscan also experience abnormalities in the development of the midline of the body, which can cause holoprosencephaly, myelomeningocele, urological anomalies, widely spaced eyes (hypertelorism), cleft palate, and abnormalities of the sacral spine and anus. Heterotaxia with recurrent respiratory infections are called primary ciliary dyskinesia. heterotaxy, visceral, X-linked MESH:C538116 DOID:0051016 visceral heterotaxy caused by mutation in ZIC3 UMLS:C1844020 MEDGEN:336609 heterotaxy, visceral, 1, X-linked GARD:0008591 congenital heart defects, nonsyndromic, 1, X-linked, X-linked recessive ZIC3 visceral heterotaxy HTX1 MONDO:0010607 visceral heterotaxy