syndromic disease paraplegia-intellectual disability-hyperkeratosis syndrome https://www.malacards.org/card/impaired_intellectual_development_with_spastic_paraplegia_and_palmoplantar_hyperkeratosis https://www.malacards.org/card/paraplegia_intellectual_disability_hyperkeratosis_syndrome MEDGEN:411554 mental retardation with spastic paraplegia and palmoplantar hyperkeratosis MESH:C537058 MONDO:0010662 Orphanet:2824 OMIM:309560 Fitzsimmons-McLachlan-Gilbert syndrome UMLS:C2745996 A syndrome characterized by intellectual deficit, spasticity in the lower limbs (spastic paraplegia), pes cavus deformity of both feet, an abnormal gait, and palmar and plantar hyperkeratosis. It has been reported in four brothers. The mother of the affected boys had normal intelligence, plantar hyperkeratosis and a strong facial resemblance to her retarded sons. Her three daughters were normal. This syndrome most likely an X-linked recessive condition. GARD:0002344 multiple congenital anomalies/dysmorphic syndrome-intellectual disability X-linked syndromic intellectual disability