has material basis in germline mutation in disease has basis in disruption of disease caused by disruption of IDS iduronate-2-sulfatase activity syndromic disease mucopolysaccharidosis type 2 https://github.com/monarch-initiative/mondo/issues/3787 https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/4948 https://www.malacards.org/card/mucopolysaccharidosis_type_ii NCIT:C61260 Hunter syndrome mucopolysaccharidosis, type II NORD:1255 MedDRA:10056889 Orphanet:79388 icd11.foundation:1056274204 IDS deficiency mucopolysaccharidosis type 2 mucopolysaccharidosis II, X-linked recessive Orphanet:580 MPSII SIDS deficiency OMIM:309900 NANDO:1200097 MONDO:0010674 MPS 2 Hunter's syndrome NANDO:2200548 MPS II MEDGEN:7734 attenuated MPS (subtype; formerly known as mild MPS II) MESH:D016532 ICD10CM:E76.1 UMLS:C0026705 SCTID:70737009 GARD:0006675 iduronate 2-sulfatase deficiency Mucopolysaccharidosis Type II mucopolysaccharidosis type II DOID:12799 A lysosomal storage disease leading to a massive accumulation of glycosaminoglycans and a wide variety of symptoms including distinctive coarse facial features, short stature, cardio-respiratory involvement and skeletal abnormalities. It manifests as a continuum varying from a severe to an attenuated form without neuronal involvement. sulfoiduronate sulfatase deficiency severe MPS II MPS with skin involvement mucopolysaccharidosis with skin involvement MPS2 mucopolysaccharidosis, type 2 I2S deficiency obsolete syndromic neurometabolic disease with X-linked intellectual disability obsolete lysosomal disease with hypertrophic cardiomyopathy mucopolysaccharidosis obsolete metabolic disease with skin involvement obsolete lysosomal storage disease with skeletal involvement obsolete eyelids malposition disorder lysosomal storage disease with skeletal involvement