has material basis in germline mutation in PLP1 hereditary spastic paraplegia 2 https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/spastic_paraplegia_2_x_linked spastic paraplegia 2, X-linked, X-linked recessive UMLS:C0751604 GARD:0004923 Spastic paraplegia type 2 (SPG2) is an X-linked leukodystrophy characterized primarily by spastic gait and autonomic dysfunction. When additional central nervous system (CNS) signs, such as intellectual deficit, ataxia, or extrapyramidal signs, are present, the syndrome is referred to as complicated SPG. hereditary spastic paraplegia type 2 spastic paraplegia 2, X-linked OMIM:312920 PLP1 hereditary spastic paraplegia hereditary spastic paraplegia caused by mutation in PLP1 SPG2 DOID:0110773 MONDO:0010733 spastic gait type 2 spastic paraplegia 2 Orphanet:99015 spastic paraparesis type 2 spastic paraplegia type 2 SCTID:723622007 MEDGEN:199692 X-linked spastic paraplegia type 2 leukodystrophy hereditary spastic paraplegia