has material basis in germline mutation in ZC4H2 congenital nervous system disorder Wieacker-Wolff syndrome https://github.com/monarch-initiative/mondo/issues/3680 https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/9285 https://www.malacards.org/card/wieacker_wolff_syndrome Miles-Carpenter syndrome A severe X-linked recessive neurodevelopmental disorder characterized by severe contractures (arthrogryposis) and intellectual disability. DOID:0060815 mental retardation, X-linked, with congenital contractures and Low fingertip arches foot contractures-muscle atrophy-oculomotor apraxia syndrome MESH:C536703 GARD:0007890 contractures of feet, muscle atrophy, and oculomotor apraxia MCS OMIM:314580 intellectual disability-developmental delay-contractures syndrome UMLS:C0796200 Wieacker-Wolff syndrome ZC4H2-Associated Rare Disorders (ZARD) mental retardation, X-linked, with congenital contractures and low fingertip arches Orphanet:3454 mental retardation, X-linked, syndromic 4 Wieacker-Wolff syndrome, X-linked MESH:C537472 X-linked intellectual disability, Miles-Carpenter type Wieacker-Wolff syndrome, X-linked recessive MONDO:0010758 Orphanet:85283 MRXS4 MEDGEN:163227 WRWF apraxia, oculomotor, with congenital contractures and muscle atrophy WRWFXLR Wieacker syndrome SCTID:722456001 NORD:91159 Miles-CARPENTER X-linked mental retardation syndrome SCTID:719012009 Wieacker Wolff syndrome multiple congenital anomalies/dysmorphic syndrome-intellectual disability X-linked syndromic intellectual disability Wieacker-Wolff syndrome (spectrum) Mendelian neurodevelopmental disorder