syndromic disease hemolytic anemia lethal hemolytic anemia-genital anomalies syndrome https://github.com/monarch-initiative/mondo/issues/6878 https://www.malacards.org/card/hemolytic_anemia_lethal_congenital_nonspherocytic_with_genital_and_other_abnormalities_2 https://www.malacards.org/card/lethal_hemolytic_anemia_genital_anomalies_syndrome hemolytic anaemia lethal congenital nonspherocytic with genital and other abnormalities hemolytic anemia lethal congenital nonspherocytic with genital and other abnormalities Orphanet:1046 MESH:C563935 hemolytic anemia, lethal congenital nonspherocytic, with genital and other abnormalities GARD:0002642 OMIM:600461 Waters-West syndrome is characterized by the association of lethal non-spherocytic, non-immune hemolytic anemia with abnormalities of the external genitalia (micropenis and hypospadias), flat occiput, dimpled earlobes, deep plantar creases, and increased space between the first and second toes. It has been described only once in two brothers who died a few hours after birth. The second-born infant had massive ascites and hepatosplenomegaly. The mother had two spontaneous abortions (at 6 and 12 weeks gestation) but gave birth to a normal girl, suggesting an autosomal or X-linked recessive mode of inheritance. Although the parents were not known to be consanguineous, they shared a French-Canadian and American Indian ethnic origin. water-West syndrome MEDGEN:333019 UMLS:C1838120 MONDO:0010891