has characteristic has characteristic has material basis in germline mutation in PCSK1 obesity due to prohormone convertase I deficiency https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/proprotein_convertase_1_3_deficiency MEDGEN:318777 MONDO:0010961 Orphanet:71528 Prohormone convertase-I deficiency is the rarest form of monogenic obesity. The disorder is characterized by severe childhood obesity, hypoadrenalism, reactive hypoglycaemia, and elevated circulating levels of certain prohormones. GARD:0016689 PCSK1 Deficiency PCI deficiency MESH:C563423 obesity and endocrinopathy due to impaired processing of prohormones DOID:0111698 NORD:109523 SCTID:722053001 UMLS:C1833053 proprotein convertase 1/3 deficiency OMIM:600955 congenital hypogonadotropic hypogonadism inherited obesity congenital