syndromic intellectual disability MMEP syndrome https://github.com/monarch-initiative/mondo/issues/5588 https://www.malacards.org/card/microphthalmia_syndromic_8_2 Viljoen-Smart syndrome MESH:C537686 Viljoen Smart syndrome microphthalmia, syndromic 8 SCTID:715533002 Orphanet:3434 MEDGEN:330469 microcephaly microphthalmia ectrodactyly of lower limbs and prognathism microcephaly-microphthalmia-ectrodactyly of lower limbs-prognathism syndrome DOID:0111803 MONDO:0011045 A congenital syndromic form of split-hand/foot malformation (SHFM). It is characterized by microcephaly, microphthalmia, ectrodactyly of the lower limbs and prognathism. Intellectual deficit has been reported. MMEP syndrome is considered to be a very rare condition, although the exact prevalence remains unknown. The etiology is not completely understood. Disruption of the sorting nexin 3 gene (SNX3; 6q21) has been shown to play a causative role in MMEP, although this was not confirmed in recent studies. microphthalmia syndromic 8 MCOPS8 MMEP GARD:0003693 syndromic microphthalmia type 8 OMIM:601349 UMLS:C1832440 multiple congenital anomalies/dysmorphic syndrome-intellectual disability syndromic microphthalmia