has characteristic has characteristic has material basis in germline mutation in SDHAF2 Autosomal dominant inheritance autosomal dominant disease paraganglioma central nervous system cancer malignant urinary system neoplasm pheochromocytoma/paraganglioma syndrome 2 https://github.com/monarch-initiative/mondo/issues/9178 https://rarediseases.info.nih.gov/diseases/10544/paragangliomas-2 https://www.malacards.org/card/pheochromocytoma_paraganglioma_syndrome_2 MEDGEN:357076 DOID:0061217 SDHAF2 paraganglioma GARD:0010544 SDHAF2-related hereditary paraganglioma-pheochromocytoma syndrome (paragangliomas 2) pheochromocytoma/paraganglioma syndrome 2 MESH:C566646 paraganglioma caused by mutation in SDHAF2 SDHAF2-related tumor predisposition An autosomal dominant tumor predisposition disorder caused by pathogenic variants in the SDHAF2 gene, characterized by an increased risk of paraganglioma, particularly head and neck paragangliomas. OMIM:601650 PGL2 paragangliomas 2 UMLS:C1866552 MONDO:0011121 paragangliomas type 2 hereditary neoplastic syndrome hereditary pheochromocytoma-paraganglioma malignant endocrine neoplasm peripheral nervous system cancer