syndromic disease lymphedema-atrial septal defects-facial changes syndrome https://github.com/monarch-initiative/mondo/issues/6878 https://rarediseases.info.nih.gov/diseases/284/irons-bhan-syndrome https://www.malacards.org/card/lymphedema_cardiac_septal_defects_and_characteristic_facies GARD:0000284 Irons-Bianchi syndrome lymphedema, atrial septal defect, and characteristic facies Irons Bhan syndrome lymphedema, atrial septal defect, and characteristic facial changes OMIM:601927 SCTID:721978002 UMLS:C2677167 MEDGEN:383042 MESH:C535539 MONDO:0011166 lymphedema, CARDIAC septal defects, and characteristic facies MESH:C567398 Orphanet:86915 Irons-Bhan syndrome Lymphedema-atrial septal defects-facial changes syndrome is characterized by congenital lymphoedema of the lower limbs, atrial septal defect and a characteristic facies (a round face with a prominent forehead, a flat nasal bridge with a broad nasal tip, epicanthal folds, a thin upper lip and a cleft chin). It has been described in two brothers and a sister. Transmission appears to be autosomal recessive. autosomal recessive syndrome of lymphedema, hydroceles, atrial septal defect, and characteristic facial changes primary lymphedema