has material basis in germline mutation in YY1AP1 hereditary disease grange syndrome https://www.malacards.org/card/grange_syndrome GARD:0016697 MONDO:0011243 OMIM:602531 progressive arterial occlusive disease-hypertension-heart defects-bone fragility-brachysyndactyly syndrome grange occlusive arterial syndrome MESH:C566529 Orphanet:79094 SCTID:717824007 UMLS:C1865267 icd11.foundation:729368905 MEDGEN:355427 GRNG Grange syndrome is characterized by stenosis or occlusion of multiple arteries (including the renal, cerebral and abdominal vessels), hypertension, brachysyndactyly, syndactyly, increased bone fragility, and learning difficulties or borderline intellectual deficit. Congenital heart defects were also reported in some cases. grange syndrome multiple congenital anomalies/dysmorphic syndrome without intellectual disability