has material basis in germline mutation in SLC25A13 citrullinemia, type II, adult-onset https://github.com/monarch-initiative/mondo/issues/4521 https://rarediseases.info.nih.gov/diseases/10215/adult-onset-citrullinemia-type-ii https://www.malacards.org/card/citrullinemia_type_ii_adult_onset citrullinemia type 2 citrullinemia, type II, adult-onset Adult-onset citrullinemia type II is an inherited disorder that causes ammonia and other toxic substances to accumulate in the blood. The condition chiefly affects the nervous system, causing confusion, restlessness, memory loss, abnormal behaviors (such as aggression, irritability, and hyperactivity), seizures, and coma. These signs and symptoms can be life-threatening. The signs and symptoms appear during adulthood and are triggered by certain medications, infections, surgery, and alcohol intake.The features of adult-onset type II citrullinemia may also develop in people who as infants had a liver disorder called neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD). In many cases, the signs and symptoms of NICCD resolve within a year. Years or even decades later, however, some of these people develop the characteristic features of adult-onset type II citrullinemia.adult-onset citrullinemia type II is caused by mutations in the SLC25A13 gene. This condition is inherited in an autosomal recessive pattern. OMIM:603471 MONDO:0011326 citrin deficiency citrullinemia, adult-onset type II citrullinemia type II adult-onset citrullinemia type 2 CTLN2 TODO - merge into parent NANDO:1200980 adult-onset citrullinemia type II GARD:0024789 DOID:0070342 citrullinemia type II