has material basis in germline mutation in MOCOS xanthinuria type II https://rarediseases.info.nih.gov/diseases/5620/xanthinuria-type-2 https://www.malacards.org/card/xanthinuria_type_ii xanthinuria, type 2 XDH and AOX dual deficiency MESH:C566358 DOID:0070453 xanthine dehydrogenase and aldehyde oxidase combined deficiency of MEDGEN:350953 UMLS:C1863688 MONDO:0011346 xanthine dehydrogenase and xanthine aldehyde oxidase dual deficiency type 2 xanthinuria xanthinuria type 2 xanthine dehydrogenase and aldehyde oxidase, combined deficiency of type II xanthinuria XAN2 xanthinuria, type II Orphanet:93602 OMIM:603592 GARD:0005620 Type II xanthinuria, a type of classical xanthinuria, is a rare autosomal recessive disorder of purine metabolism characterized by the deficiency of both xanthine dehydrogenase and aldehyde oxidase, leading to the formation of urinary xanthine urolithiasis and leading, in some patients, to kidney failure. Other less common manifestations include arthropathy, myopathy and duodenal ulcer, while some patients remain asymptomatic. hereditary xanthinuria