has material basis in germline mutation in HBB autosomal recessive disease sickle cell disease https://github.com/monarch-initiative/mondo/issues/7391 https://github.com/monarch-initiative/mondo/issues/9097 https://www.malacards.org/card/sickle_cell_disease HPA1 NCIT:C34383 HbS disease sickling disorder due to Hemoglobin S Hemoglobin S disease ICD9:282.60 ICD9:282.63 NANDO:2200624 DOID:10923 Haemoglobin S disease without crisis UMLS:C0002895 GARD:0008614 sickle-cell/Hb-C disease without crisis ICD9:282.6 Orphanet:232 MedDRA:10040641 Sickle Cell Disease Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur. Hb-S/Hb-C disease MESH:D000755 DOID:0081445 MEDGEN:287 ICD10CM:D57.2 OMIM:603903 sickle cell disease sickling disorder due to Haemoglobin S HPA 1 recognition polymorphism, beta-globin-related Haemoglobin S disease MONDO:0011382 sickle cell anemia NORD:1714 congenital hypogonadotropic hypogonadism secondary avascular necrosis obsolete avascular necrosis of genetic origin inherited hemoglobinopathy