has material basis in germline mutation in LORICRIN loricrin keratoderma https://github.com/monarch-initiative/mondo/issues/2114 https://github.com/monarch-initiative/mondo/issues/6749 https://github.com/monarch-initiative/mondo/issues/6877 https://www.malacards.org/card/vohwinkel_syndrome_variant_form MONDO:0011396 MESH:C565826 MEDGEN:395099 keratoderma hereditarium mutilans with ichthyosis loricrin keratoderma mutilating keratoderma with ichthyosis Vohwinkel syndrome with ichthyosis SCTID:717183001 GARD:0016719 Vohwinkel syndrome, variant form A diffuse palmoplantar keratoderma, characterized by honeycomb palmoplantar hyperkeratosis associated with pseudoainhum of the fifth digit of the hand, ichthyosis and deafness. Keratoderma hereditarium mutilans with ichthyosis follows an autosomal dominant mode of transmission. keratoderma-ichthyosiform dermatosis-elevated beta-glucuronidase syndrome UMLS:C1858805 OMIM:604117 Camisa disease Orphanet:79395 diffuse palmoplantar keratoderma