has material basis in germline mutation in KIF5A hereditary spastic paraplegia 10 https://www.malacards.org/card/spastic_paraplegia_10_autosomal_dominant GARD:0009590 SPG10 MONDO:0011408 MEDGEN:349003 SCTID:732948003 UMLS:C1858712 hereditary spastic paraplegia caused by mutation in KIF5A OMIM:604187 Autosomal dominant spastic paraplegia type 10 (SPG10) is a rare type of hereditary spastic paraplegia that can present as either a pure form of spastic paraplegia with lower limb spasticity, hyperreflexia and extensor plantar responses, presenting in childhood or adolescence, or as a complex phenotype associated with additional manifestations including peripheral neuropathy with upper limb amyotrophy, moderate intellectual disability and parkinsonism. Deafness and retinitis pigmentosa were reported in one case. spastic paraplegia 10, autosomal dominant Orphanet:100991 DOID:0110763 hereditary spastic paraplegia type 10 autosomal dominant spastic paraplegia KIF5A hereditary spastic paraplegia spastic paraplegia 10 MESH:C537482 autosomal dominant spastic paraplegia type 10 hereditary spastic paraplegia KIF5A-related neurological disorder