has material basis in germline mutation in NR3C2 hereditary disease pseudohyperaldosteronism type 2 https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/hypertension_early_onset_autosomal_dominant_with_severe_exacerbation_in_pregnancy https://www.malacards.org/card/pseudohyperaldosteronism_type_2 MONDO:0011517 SCTID:766937004 hypertension, early-onset, autosomal dominant, with Severe exacerbation in pregnancy hypertension due to gain-of-function mutations in the mineralocorticoid receptor hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy Orphanet:88660 hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy Hypertension due to gain-of-function mutations in the mineralocorticoid receptor is a rare genetic hypertension characterized by a familial severe hypertension with an onset before age 20 years, associated with suppressed plasma renin and low aldosterone levels in the presence of low or normal levels of the mineralocorticoid aldosterone, that is highly resistant to antihypertensive medication. During pregnancy, there is a marked exacerbation of hypertension, accompanied by low serum potassium levels and undetectable aldosterone levels, but without signs of preeclampsia, requiring early delivery. early-onset hypertension with exacerbation in pregnancy GARD:0019093 OMIM:605115 MEDGEN:343170 icd11.foundation:538048714 UMLS:C1854631 MESH:C565359 pregnancy disorder