spinal muscular atrophy autosomal recessive distal spinal muscular atrophy 2 https://www.malacards.org/card/neuronopathy_distal_hereditary_motor_autosomal_recessive_2 SCTID:763533003 UMLS:C1854023 dHMNJ HMNJ spinal muscular atrophy, distal, autosomal recessive, type 2 MNDJ MESH:C535715 MONDO:0011585 hereditary motor neuropathy, Jerash type autosomal recessive distal spinal muscular atrophy type 2 DOID:0111065 OMIM:605726 Distal hereditary motor neuropathy, Jerash type is a rare, genetic neuromuscular disease characterized by progressive, symmetrical, moderate to severe, distal muscle weakness and atrophy, without sensory involvement, first affecting the lower limbs (towards the end of the first decade) and then involving (within two years) the upper extremities. Patients typically develop foot drop, pes varus, hammer toes and claw hands. Pyramidal tract signs (e.g. brisk knee reflexes, positive Babinski sign, absent ankle reflexes) are initially associated but regress as disease stabilizes (~10 years after onset). spinal muscular atrophy, distal, autosomal recessive, 2 Orphanet:139552 motor neuropathy, distal, Jerash type GARD:0010133 MEDGEN:344189 neuropathy, distal hereditary motor, Jerash type DSMA2 neuronopathy, distal hereditary motor, autosomal recessive