disease has major feature congenital nervous system disorder heart disorder PHACE syndrome https://www.malacards.org/card/phace_association https://www.malacards.org/card/phace_syndrome Phaces association Posterior fossa brain malformations, hemangiomas of the face, arterial anomalies, cardiac anomalies, and eye abnormalities aortic aneurysm, giant congenital icd11.foundation:1825849023 NORD:1927 MEDGEN:376231 Orphanet:42775 GARD:0008338 MONDO:0011676 PHACE association MedDRA:10068032 pascual-Castroviejo type II syndrome P-CIIS OMIM:606519 UMLS:C1847874 pascual-Castroviejo syndrome type 2 PHACE is an acronym used to describe a syndrome characterized by the association of posterior fossa brain malformations, large facial haemangiomas, anatomical anomalies of the cerebral arteries, aortic coarctation and other cardiac anomalies, and eye abnormalities. Sternal anomalies are also sometimes present, and in these cases the syndrome is referred to as PHACES. Two additional manifestations have recently been added to the clinical spectrum of PHACE syndrome: stenosis of the vessels at the base of the skull and segmental longitudinal dilations of the internal carotid artery. obsolete neurovascular malformation multiple congenital anomalies/dysmorphic syndrome-variable intellectual disability syndrome obsolete vascular tumor with associated anomalies obsolete genetic vascular tumor obsolete Moyamoya syndrome central nervous system malformation obsolete palpebral tumor with a vascular malformation