has material basis in germline mutation in PAFAH1B1 lissencephaly due to LIS1 mutation https://www.malacards.org/card/lissencephaly_1 https://www.malacards.org/card/lissencephaly_due_to_lis1_mutation Orphanet:95232 GARD:0016838 LIS1 DOID:0112237 lissencephaly, classic subcortical laminar heterotopia lissencephaly 1 Lissencephaly due to LIS1 mutation is a cerebral malformation with epilepsy characterized predominantly by posterior isolated lissencephaly with developmental delay, intellectual disability and epilepsy that usually evolves from West syndrome to Lennox-Gastaut syndrome. Additional features include muscular hypotonia, acquired microcephaly, failure to thrive and poor control of airways leading to aspiration pneumonia. MEDGEN:1657090 PAFAH1B1-related lissencephaly MONDO:0011830 lissencephaly sequence, isolated UMLS:C4749301 OMIM:607432 subcortical band heterotopia classic lissencephaly