has material basis in germline mutation in GRN GRN-related frontotemporal lobar degeneration with Tdp43 inclusions https://www.malacards.org/card/frontotemporal_dementia_2 MEDGEN:375285 MONDO:0011842 OMIM:607485 GARD:0010004 UMLS:C1843792 DOID:0060672 A frontotemporal dementia characterized by variable phenotypic expression typically including social, behavioral, or language deterioration, rather than memory or motor deficits and the presence of TARDBP-positive inclusions that has material basis in mutation in the GRN gene on chromosome 17q21.31. frontotemporal dementia primary progressive aphasia