Curly hair - acral keratoderma - caries syndrome https://rarediseases.info.nih.gov/diseases/10163/curly-hair-acral-keratoderma-caries-syndrome https://www.malacards.org/card/curly_hair_acral_keratoderma_caries_syndrome Orphanet:307766 UMLS:C1843291 CHACS Chac syndrome Curly hair-acral keratoderma-caries syndrome is an extremely rare ectodermal dysplasia syndrome characterized by premature loss of curly, brittle, dry hair, premature loss of teeth due to caries, nail dystrophy with thickening of the finger- and toe-nails, acral keratoderma and hypohidrosis. Additionally, sparse eyebrows and eyelashes, receding frontal hairline and flattened malar region are associated. The severity of features appears to increase with age. OMIM:607656 MEDGEN:335923 MONDO:0011883 MESH:C536220 Curly hair - acral keratoderma - caries syndrome GARD:0010163 diffuse palmoplantar keratoderma ectodermal dysplasia syndrome