has material basis in germline mutation in IRAK4 immunodeficiency 67 https://www.malacards.org/card/immunodeficiency_67 https://www.malacards.org/card/transient_predisposition_to_invasive_pyogenic_bacterial_infection MEDGEN:375137 invasive pneumococcal disease, recurrent isolated, type 1 MESH:C564352 immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency Orphanet:70592 IRAK-4 deficiency MESH:C563662 IRAK4D IRAK4 deficiency NANDO:1200361 invasive pneumococcal disease, recurrent isolated, 1 GARD:0010311 immunodeficiency 67 An immunodeficiency associated with increased susceptibility to invasive infections caused by pyogenic bacteria. OMIM:607676 IPD1 MONDO:0011888 NANDO:2200762 Interleukin receptor-associated kinase deficiency UMLS:C1843256 immunodeficiency disease