has material basis in germline mutation in BCR myeloid leukemia chronic myeloid leukemia https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/9892 https://www.malacards.org/card/chronic_myelogenous_leukemia_bcr_abl1_positive https://www.malacards.org/card/leukemia_chronic_myeloid GARD:0006105 UMLS:C0279543 CML - chronic myelogenous leukaemia chronic myelocytic leukemia DOID:0081088 ICDO:9875/3 Orphanet:521 chronic granulocytic leukemia ICD9:205.1 leukimia, chronic myeloid DOID:8552 hematopoeitic - chronic myelocytic leukaemia (CML) chronic myelogenous leukemia, BCR-ABL1 Positive ICDO:9863/3 BCR-ABL Positive chronic myelogenous leukaemia chronic myelogenous leukemia chronic myelogenous leukemia (CML) MedDRA:10009013 hematopoeitic - chronic myelocytic leukemia (CML) chronic myelogenous leukaemia (CML) A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival. ONCOTREE:CML chronic myelogenous leukemias NCIT:C3174 OMIM:608232 CML - chronic myelogenous leukemia BCR-ABL Positive chronic myelogenous leukemia myeloid leukemia, chronic chronic myeloid leukemia CML chronic myelocytic leukaemia NANDO:2200013 EFO:0000339 MEDGEN:75993 MONDO:0011996 hereditary disorder of connective tissue