has material basis in germline mutation in DDC aromatic L-amino acid decarboxylase deficiency https://github.com/monarch-initiative/mondo/issues/9097 https://rarediseases.info.nih.gov/diseases/770/aromatic-l-amino-acid-decarboxylase-deficiency https://www.malacards.org/card/aromatic_l_amino_acid_decarboxylase_deficiency NANDO:1200988 GARD:0000770 ICD9:270.8 Aromatic L-amino acid decarboxylase deficiency is a very rare, severe, genetic neurometabolic disorder associated with clinical manifestations related to underproduction of serotonin and dopamine, mainly hypotonia, hypokinesia, ptosis oculogyric crises, and signs of autonomic dysfunction. Aadc deficiency ICD10CM:E70.81 SCTID:237922009 MESH:C537437 UMLS:C1291564 aromatic amino acid decarboxylase deficiency OMIM:608643 NORD:2010 aromatic L-amino acid decarboxylase deficiency Orphanet:35708 DDC deficiency NCIT:C142085 NANDO:2200596 Dopa decarboxylase deficiency MEDGEN:220945 MONDO:0012084 AADC deficiency DOID:0090123 icd11.foundation:1134258245 aromatic L-amino-acid decarboxylase deficiency disorder of catecholamine synthesis