has material basis in germline mutation in SLC27A4 integumentary system disorder syndromic disease hereditary disease ichthyosis prematurity syndrome https://github.com/monarch-initiative/mondo/issues/6749 https://github.com/monarch-initiative/mondo/issues/6877 https://github.com/monarch-initiative/mondo/issues/6878 https://rarediseases.info.nih.gov/diseases/9886/ichthyosis-prematurity-syndrome https://www.malacards.org/card/ichthyosis_prematurity_syndrome MEDGEN:324839 GARD:0009886 IPS ichthyosis congenita 4 MONDO:0012089 MESH:C536271 Ichthyosis prematurity syndrome is a rare, syndromic congenital ichthyosis characterized by premature birth (at gestational weeks 30-32, in general) in addition to thick, caseous and desquamating epidermis, neonatal respiratory asphyxia, and persistent eosinophilia. After the perinatal period, a spontaneous improvement in the health of affected patients is observed and skin features (vernix caseosa-like scale) evolve into a mild presentation of flat follicular hyperkeratosis with atopy. ichthyosis congenita IV UMLS:C1837610 SCTID:12381000132107 NCIT:C62590 ichthyosis prematurity syndrome OMIM:608649 congenital ichthyosis type 4 Orphanet:88621 idiopathic pneumonia syndrome ichthyosis-prematurity syndrome pneumonitis