has material basis in germline mutation in predisposes towards CD8A susceptibility to respiratory infections associated with CD8alpha chain mutation https://www.malacards.org/card/immunodeficiency_116 MONDO:0012161 MESH:C563824 NANDO:1200326 UMLS:C1837065 NANDO:2200699 CD8 deficiency, familial Orphanet:169085 familial CD8 deficiency susceptibility to respiratory infections associated with CD8alpha chain mutation GARD:0017047 DOID:0061082 SCTID:766983005 Susceptibility to respiratory infections associated with CD8 alpha chain mutation is a rare primary immunodeficiency due to a defect in adaptive immunity characterized by the absence of CD8+ T cells with normal immunoglobulin and specific antibody titres in blood and susceptibility to recurrent respiratory bacterial and viral infections. Symptom severity range from fatal respiratory insufficiency to mild or asymptomatic phenotypes. MEDGEN:323058 OMIM:608957 non-SCID combined immunodeficiency inherited disease susceptibility respiratory tract infectious disorder