disease has primary infectious agent disease causes dysfunction of disease has infectious agent CD4-positive helper T cell T-cell immunodeficiency HIV infectious disease infectious disease AIDS https://www.malacards.org/card/acquired_immunodeficiency_syndrome acquired immunodeficiency syndrome AIDS acquired immunodeficiency disease NCIT:C2851 DOID:635 MEDGEN:99 AIDS, acquired immunodeficiency syndrome SCTID:62479008 A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. NANDO:2200809 acquired immunodeficiency syndrome, AIDS NANDO:2100212 UMLS:C0001175 MESH:D000163 EFO:0000765 MONDO:0012268 acquired immune deficiency Human immunodeficiency virus