has material basis in germline mutation in C5 classic complement early component deficiency complement deficiency complement component 5 deficiency https://www.malacards.org/card/complement_component_5_deficiency C5 complement deficiency UMLS:C0343047 MEDGEN:91003 MONDO:0012295 C5D DOID:8158 GARD:0002191 NANDO:2200783 OMIM:609536 complement component 5 deficiency NCIT:C9469 dysfunction of the fifth component of complement (C5) C5 deficiency complement deficiency caused by mutation in C5 A rare genetic disorder with an autosomal recessive pattern of inheritance. It is caused by the ineffective or decreased biosynthesis of the fifth complement component, C5. C5 deficiency may also be acquired acutely post-infection. If C5 is adequately synthesized, its rapid depletion may result in a functional deficiency. Clinical signs of the inherited deficiency present within the second decade of life and are consistent with the signs of recurrent systemic infection. Deficiency of serum C5 and its major cleavage product, C5b, a component of the membrane attack complex, increases susceptibility to Neisserial infections. immunodeficiency due to a late component of complement deficiency