has material basis in germline mutation in CTSD neuronal ceroid lipofuscinosis 1 neuronal ceroid lipofuscinosis 10 https://rarediseases.info.nih.gov/diseases/1218/neuronal-ceroid-lipofuscinosis-10 https://www.malacards.org/card/ceroid_lipofuscinosis_neuronal_10_2 MEDGEN:350481 DOID:0110725 OMIM:610127 CLN10-NCL CLN10 disease, adult (subtype) SCTID:720831008 Orphanet:228337 A rare condition that affects the nervous system. Signs and symptoms of the condition can develop any time from birth to adulthood and may include progressive dementia, seizures, lack of muscle coordination, and vision loss. CLN10-NCL is caused by changes (mutations) in the CTSD gene and is inherited in an autosomal recessive manner. Treatment options are limited to therapies that can help relieve some of the symptoms. neuronal ceroid lipofuscinosis due to cathepsin D deficiency CLN10 ceroid lipofuscinosis neuronal Cathepsin D-deficient UMLS:C1864669 ceroid lipofuscinosis, neuronal, type 10 CLN10 disease, congenital (subtype) CLN10 disease, late infantile (subtype) MESH:C566438 CTSD neuronal ceroid lipofuscinosis GARD:0001218 neuronal ceroid lipofuscinosis caused by mutation in CTSD neuronal ceroid lipofuscinosis type 10 CLN10 disease, juvenile (subtype) MONDO:0012414 ceroid lipofuscinosis, neuronal, 10 neuronal ceroid lipofuscinosis