has material basis in germline mutation in disease has basis in disruption of disease caused by disruption of ALDH2 aldehyde dehydrogenase (NAD+) activity hereditary disease alcohol sensitivity, acute https://rarediseases.info.nih.gov/diseases/12634/acute-alcohol-sensitivity https://www.malacards.org/card/alcohol_sensitivity_acute acute alcohol sensitivity alcohol intolerance UMLS:C2674838 Alcohol intolerance is characterized by immediate unpleasant reactions after drinking alcohol. The most common signs and symptoms of alcohol intolerance are stuffy nose and skin flushing. Alcohol intolerance is caused by a genetic condition in which the body is unable to break down alcohol efficiently, usually found in Asians. These individuals accumulate acetaldehyde, the primary metabolite of ethanol, because of a genetic polymorphism of aldehyde dehydrogenase (ALDH) that metabolizes acetaldehyde to nontoxic acetate. The only way to prevent alcohol intolerance reactions is to avoid alcohol. Alcohol intolerance isn't an allergy. However, in some cases, what seems to be alcohol intolerance may be a reaction to something in an alcoholic beverage, such as chemicals, grains or preservatives. Combining alcohol with certain medications also can cause reactions. In rare instances, an unpleasant reaction to alcohol can be a sign of a serious underlying health problem that requires diagnosis and treatment. MONDO:0012454 OMIM:610251 alcohol sensitivity, acute MEDGEN:390639 acute disease alcohol-related disorders