has material basis in germline mutation in disease has basis in disruption of disease caused by disruption of TPMT thiopurine S-methyltransferase activity thiopurine metabolic disease thiopurine S-methyltransferase deficiency https://www.malacards.org/card/poor_metabolism_of_thiopurines https://www.malacards.org/card/thiopurines_poor_metabolism_of_1 thiopurine S-methyltransferase deficiency TPMT deficiency poor metabolism of thiopurines-1 Orphanet:3315 icd11.foundation:1916778396 UMLS:C0342801 inborn error of thiopurine S-methyltransferase activity MESH:C536512 OMIM:610460 DOID:0080172 THPM1 GARD:0005173 NCIT:C4389 thiopurine S methyltranferase deficiency DOID:0061004 6-mercaptopurine sensitivity An inherited metabolic disease that is has its basis in the disruption of thiopurine S-methyltransferase activity. inborn thiopurine S-methyltransferase activity disorder rare inborn error of thiopurine S-methyltransferase activity MEDGEN:83352 SCTID:238012003 thiopurine methyltransferase deficiency MONDO:0012503 inborn errors of metabolism