has material basis in germline mutation in INSR endocrine pancreas disorder hereditary disease diabetes mellitus insulin-resistance syndrome type A https://github.com/monarch-initiative/mondo/issues/5723 https://www.malacards.org/card/diabetes_mellitus_insulin_resistant_with_acanthosis_nigricans https://www.malacards.org/card/insulin_resistance_syndrome_type_a MESH:C562710 insulin-resistant acanthosis nigricans, type A NCIT:C131836 type A insulin resistance syndrome icd11.foundation:343459534 Orphanet:2297 GARD:0003008 Type A insulin-resistance syndrome belongs to the group of extreme insulin-resistance syndromes (which includes leprechaunism, the lipodystrophies, Rabson-Mendenhall syndrome and type B insulin resistance syndrome) and is characterized by the triad of hyperinsulinemia, acanthosis nigricans (skin lesions associated with insulin resistance), and signs of hyperandrogenism in females without lipodystrophy and who are not overweight. insulin resistant diabetes mellitus with acanthosis nigricans and hyperandrogenism UMLS:C0342278 MEDGEN:501111 OMIM:610549 MONDO:0012520