has material basis in germline mutation in F12 hereditary angioedema type 3 https://github.com/monarch-initiative/mondo/issues/10432 https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/angioedema_hereditary_3 HAE3 HAE-FXII HAE with factor 12 (F12) mutation A hereditary angioedema caused by a variation in the F12 gene, characterized by normal serum levels and function of C1 inhibitor, normal C1 activity, and, clinically, recurrent subcutaneous edema, abdominal pain attacks, and episodes of potentially life-threatening upper airway obstruction. The disorder occurs almost exclusively in women, and episodes are often precipitated or worsened by high estrogen levels (such as during pregnancy or treatment with oral contraceptives). angioedema, hereditary, 3 hereditary angioneurotic oedema type 3 UMLS:C1857728 SCTID:427167008 HAE-III inherited estrogen-associated angioneurotic edema F12-related hereditary angioedema with normal C1Inh hereditary angioneurotic edema type 3 inherited estrogen-associated angioneurotic oedema GARD:0016935 inherited estrogen-dependent angioneurotic edema inherited estrogen-dependent angioneurotic oedema F12 hereditary angioedema MEDGEN:346653 inherited estrogen-associated angioedema HAE 3 inherited estrogen-dependent angioedema MESH:D056828 hereditary angioedema type 3 DOID:0080940 Orphanet:100054 MONDO:0012526 hereditary angioedema caused by mutation in F12 OMIM:610618 ICD9:277.6 hereditary angioedema hereditary angioedema with normal C1Inh