has material basis in germline mutation in ABCA3 hereditary pulmonary alveolar proteinosis interstitial lung disease due to ABCA3 deficiency https://www.malacards.org/card/surfactant_metabolism_dysfunction_pulmonary_3 surfactant metabolism dysfunction, pulmonary, type 3 Orphanet:440402 GARD:0017745 interstitial lung disease due to ATP-binding cassette subfamily A member 3 deficiency MESH:C567046 OMIM:610921 Interstitial lung disease due to ABCA3 deficiency is a rare genetic respiratory disease characterized by a variable clinical outcome ranging from a fatal respiratory distress syndrome in the neonatal period to chronic interstitial lung disease developing in infancy or childhood with chronic cough, rapid breathing, shortness of breath and recurrent pulmonary infections. Clinical manifestations of respiratory failure include grunting, intercostal retractions, nasal flaring, cyanosis, and progressive dyspnea. surfactant metabolism dysfunction, pulmonary, 3 UMLS:C1970456 MONDO:0012582 interstitial lung disease due to ABCA3 deficiency SMDP3 MEDGEN:410074 inherited interstitial lung disease