has material basis in germline mutation in DARS2 leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome https://www.malacards.org/card/leukoencephalopathy_with_brain_stem_and_spinal_cord_involvement_high_lactate_syndrome https://www.malacards.org/card/leukoencephalopathy_with_brainstem_and_spinal_cord_involvement_and_lactate_elevation leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome Orphanet:137898 OMIM:611105 GARD:0012652 leukoencephalopathy with brain stem and spinal cord involvement - lactate elevation mitochondrial aspartyl-tRNA synthetase deficiency NORD:1941 leukoencephalopathy with brain stem and spinal cord involvement-lactate elevation syndrome leukoencephalopathy with brain stem and spinal cord involvement - high lactate MEDGEN:370845 MONDO:0012622 This disease is characterized by progressive cerebellar ataxia with pyramidal and spinal cord dysfunction, associated with distinctive MRI anomalies and increased lactate in the abnormal white matter. LBSL leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation UMLS:C1970180 SCTID:703537008 Leukoencephalopathy with Brain Stem and Spinal Cord Involvement and Lactate Elevation MESH:C567009 mitochondrial oxidative phosphorylation disorder leukodystrophy