syndromic intellectual disability microphthalmia-brain atrophy syndrome https://github.com/monarch-initiative/mondo/issues/5588 https://rarediseases.info.nih.gov/diseases/9292/microphthalmia-syndromic-10 https://www.malacards.org/card/microphthalmia_syndromic_10_2 MEDGEN:370809 SCTID:720010009 microphthalmia, syndromic 10 MOBA DOID:0111812 microphthalmia and brain atrophy UMLS:C1970013 Microphthalmia-brain atrophy (MOBA) syndrome is a rare genetic neurodegenerative disorder characterized by congenital microphthalmia, sunken eyes, blindness, microcephaly, severe intellectual disability, progressive spasticity, and seizures. Psychomotor development is normal in the first 6-8 months of life and thereafter declines rapidly and continuously. Brain MRI reveals progressive and extensive degenerative changes, especially cortex, cerebellum, brainstem, and corpus callosum atrophy, with complete loss of cerebral white matter. MOBA syndrome microphthalmia syndromic 10 GARD:0009292 OMIM:611222 MONDO:0012638 MCOPS10 Orphanet:77299 syndromic microphthalmia type 10 MESH:C566985 syndromic microphthalmia inherited neurodegenerative disorder