has material basis in germline mutation in SERPINA6 hereditary disease adrenal gland disorder corticosteroid-binding globulin deficiency https://rarediseases.info.nih.gov/diseases/13101/corticosteroid-binding-globulin-deficiency https://www.malacards.org/card/corticosteroid_binding_globulin_deficiency OMIM:611489 transcortin deficiency GARD:0013101 MEDGEN:343831 Transcortin deficiency Corticosteroid-binding globulin deficiency is a genetic disorder characterized by extreme tiredness (fatigue), particularly after physical exertion, and low blood pressure (hypotension). Corticosteroid-binding globulin (CBG) is a protein primarily produced in the liver that attaches to cortisol, a hormone with numerous functions, including maintaining blood sugar levels, protecting the body from stress, and suppressing inflammation.When cortisol is needed in the body, CBG delivers the cortisol where it is needed and releases it. Signs and symptoms of CBG deficiency vary. While some individuals may experience no symptoms, others are found to have a fatty liver and chronic pain. Some people with CBG deficiency also have chronic fatigue syndrome. CGB deficiency is caused by mutations in the SERPINA6 gene. The SERPINA6 gene is commonly also referred to as the CBG gene. Both autosomal dominant and autosomal recessive inheritance have been reported.While there is still no cure, treatment options will depend on the type and severity of symptoms present and may involve several specialists. DOID:0090030 Orphanet:199247 UMLS:C1852529 CBG deficiency corticosteroid-binding globulin deficiency MONDO:0012675