has material basis in germline mutation in TYK2 immunodeficiency 35 https://www.malacards.org/card/immunodeficiency_35 IMD35 DOID:0111989 OMIM has the synonym hyper-IgE syndrome with atypical mycobacteriosis, autosomal recessive but the clinical description does not suggest that this is a type of hyper-IgE syndrome. Some patients presented with hyper-IgE syndrome, whereas one had mildly increased serum IgE. OMIM:611521 tyrosine kinase 2 deficiency autosomal recessive mendelian susceptibility to mycobacterial diseases due to a partial deficiency caused by mutation in TYK2 Orphanet:331226 MONDO:0012682 UMLS:C1969086 TYK2 deficiency Any hereditary predisposition to infections in which the cause of the disease is a mutation in the TYK2 gene. immunodeficiency type 35 TYK2 autosomal recessive mendelian susceptibility to mycobacterial diseases due to a partial deficiency hyper-IgE syndrome with atypical Mycobacteriosis, autosomal recessive MESH:C566928 MEDGEN:409751 autosomal recessive hyper-IgE syndrome due to TYK2 deficiency GARD:0017514 immunodeficiency 35 susceptibility to infection due to TYK2 deficiency HIES with atypical Mycobacteriosis, autosomal recessive immunodeficiency disease