has material basis in germline mutation in TUBA1A lissencephaly due to TUBA1A mutation https://www.malacards.org/card/lissencephaly_3 Lissencephaly (LIS) due to TUBA1A mutation is a congenital cortical development anomaly due to abnormal neuronal migration involving neocortical and hippocampal lamination, corpus callosum, cerebellum and brainstem. A large clinical spectrum can be observed, from children with severe epilepsy and intellectual and motor deficit to cases with severe cerebral dysgenesis in the antenatal period leading to pregnancy termination due to the severity of the prognosis. Orphanet:171680 LIS3 lissencephaly 3 MEDGEN:930822 OMIM:611603 MONDO:0012703 NCIT:C148461 UMLS:C4305153 GARD:0017066 MESH:C566908 lissencephaly type 3