has material basis in germline mutation in disease has basis in disruption of disease caused by disruption of disease has feature TREH alpha,alpha-trehalase activity Vomiting Diarrhea metabolic disease diarrhea-vomiting due to trehalase deficiency https://github.com/monarch-initiative/mondo/issues/4985 https://www.malacards.org/card/trehalase_deficiency UMLS:C0268187 icd11.foundation:2025219157 ICD9:271.8 isolated trehalose intolerance This syndrome is characterized by diarrhea and vomiting after ingestion of trehalose, a disaccharide found mainly in mushrooms. MONDO:0012803 MEDGEN:75660 OMIM:612119 Orphanet:103909 GARD:0010372 MESH:C562603 SCTID:84193000 disorder of carbohydrate transmembrane transport and absorption