has material basis in germline mutation in FA2H hereditary spastic paraplegia 35 https://www.malacards.org/card/hereditary_spastic_paraplegia_35 https://www.malacards.org/card/spastic_paraplegia_35_autosomal_recessive_with_or_without_neurodegeneration Orphanet:171629 Autosomal recessive spastic paraplegia type 35 is a rare form of hereditary spastic paraplegia characterized by childhood (exceptionally adolescent) onset of a complex phenotype presenting with lower limb (followed by upper limb) spasticity with hyperreflexia and extensor plantar responses, with additional manifestations including progressive dysarthria, dystonia, mild cognitive decline, extrapyramidal features, optic atrophy and seizures. White matter abnormalities and brain iron accumulation have also been observed on brain magnetic resonance imaging. hereditary spastic paraplegia type 35 autosomal recessive spastic paraplegia type 35 DOID:0110786 MEDGEN:501249 UMLS:C3496228 OMIM:612319 MESH:C567311 spastic paraplegia 35, autosomal recessive FA2H hereditary spastic paraplegia SPG35 hereditary spastic paraplegia 35 SCTID:764688002 hereditary spastic paraplegia caused by mutation in FA2H GARD:0010538 NANDO:1200541 MONDO:0012866 hereditary spastic paraplegia