has material basis in germline mutation in RARA bilineal acute myeloid leukemia acute promyelocytic leukemia https://github.com/monarch-initiative/mondo/issues/4521 https://github.com/monarch-initiative/mondo/issues/9097 https://www.malacards.org/card/acute_promyelocytic_leukemia https://www.malacards.org/card/acute_promyelocytic_leukemia_with_pml_rara UMLS:C0023487 SCTID:110004001 APML NANDO:2200007 DOID:0081081 AML with t(15;17)(q22;q12);(PML/RARalpha) and variants AML M3 Orphanet:520 NCIT:C3182 acute promyelocytic leukaemia with PML-rara ICD10CM:C92.4 APML - acute promyelocytic leukaemia acute myeloblastic leukaemia 3 OMIM:612376 MEDGEN:44127 acute promyelocytic leukemia with PML-rara leukemia, acute promyelocytic, somatic GARD:0000538 promyelocytic leukaemia DOID:0060318 acute promyelocytic leukemia with t(15;17)(q22;q12); PML/rara acute myeloblastic leukemia 3 MONDO:0012883 ICDO:9866/3 AML with t(15;17)(q22;q12) APML - acute promyelocytic leukemia MedDRA:10001019 APL MESH:D015473 promyelocytic leukemia acute promyelocytic leukaemia with t(15;17)(q22;q12); PML/rara FAB M3 acute promyelocytic leukemia with t(15;17)(q22;q12); PML-rara EFO:0000224 acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants acute myeloid leukaemia with t(15;17)(q22;q12);(PML/RARalpha) and variants An aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue. acute promyelocytic leukaemia with t(15;17)(q22;q12); PML-rara acute promyelocytic leukemia NORD:2003 inherited acute myeloid leukemia