has material basis in germline mutation in POLD1 polyposis POLD1-related polyposis and colorectal cancer syndrome https://github.com/monarch-initiative/mondo/issues/10250 https://github.com/monarch-initiative/mondo/issues/6005 https://github.com/monarch-initiative/mondo/issues/6515 https://www.malacards.org/card/colorectal_cancer_10 POLD1 colorectal cancer MONDO:0012953 GARD:0027828 CRCS10 colorectal cancer caused by mutation in POLD1 colorectal cancer, susceptibility to, on chromosome 19q MEDGEN:436445 UMLS:C2675481 POLD1-related polyposis and colorectal cancer syndrome colorectal cancer, susceptibility to, 10 An autosomal dominant hereditary neoplastic syndrome caused by germline pathogenic POLD1 variants, characterized by the presence of colorectal polyps and colorectal cancer. OMIM:612591 hereditary neoplastic syndrome Polymerase proofreading-related adenomatous polyposis polyp of large intestine familial colorectal cancer