has material basis in germline mutation in IL1RN chronic recurrent multifocal osteomyelitis sterile multifocal osteomyelitis with periostitis and pustulosis https://github.com/monarch-initiative/mondo/issues/6747 https://www.malacards.org/card/chronic_recurrent_multifocal_osteomyelitis_2_with_periostitis_and_pustulosis MESH:C557815 MONDO:0013021 An autoinflammatory disease caused by mutations in the IL1RN gene, which encodes the IL1 receptor antagonist. It presents in infancy, and is characterized by systemic inflammation, pustular rash, bone pain, sterile osteitis, and periostitis. DOID:0061225 deficiency of the Interleukin-1 receptor antagonist MEDGEN:411230 UMLS:C2748507 autoinflammatory disease due to interleukin-1 receptor antagonist deficiency GARD:0010516 DIRA osteomyelitis, STERILE multifocal, with periostitis and pustulosis NANDO:2200439 Orphanet:210115 OMIM:612852 Interleukin-1 receptor antagonist deficiency deficiency of interleukin-1 receptor antagonist NCIT:C119056 OMPP