has material basis in germline mutation in LDHA disorder of glycogen metabolism glycogen storage disease due to lactate dehydrogenase M-subunit deficiency https://github.com/monarch-initiative/mondo/issues/4985 https://rarediseases.info.nih.gov/diseases/3160/lactate-dehydrogenase-a-deficiency OMIM:612933 glycogen storage disease caused by mutation in LDHA GSD 11 NANDO:1200833 glycogen storage disease type 11 GSD type 11 HGNC:6535 GSD11 glycogenosis due to lactate dehydrogenase M-subunit deficiency LDH-M subunit deficiency Orphanet:284426 glycogen storage disease XI MESH:C538133 GSD XI ICD9:271.8 MONDO:0013047 A condition that affects how the body breaks down sugar to use as energy in muscle cells. People withthis conditionexperience fatigue, muscle pain, and cramps during exercise (exercise intolerance). In some people,high-intensity exercise or other strenuous activity leads to the breakdown of muscle tissue (rhabdomyolysis), which can lead to myoglobinuria (rust-colored urine indicating breakdown of muscle tissue) and kidney damage. A skin rash may also develop. The severity of the signs and symptoms varies greatly among affected individuals. Lactate dehydrogenase A deficiency is caused by mutations in the LDHA gene. This condition is inherited in an autosomal recessive pattern. SCTID:237982007 GSD due to lactate dehydrogenase M-subunit deficiency GARD:0003160 UMLS:C2931743 lactate dehydrogenase deficiency type A LDHA glycogen storage disease lactate dehydrogenase A deficiency glycogenosis type 11 MEDGEN:419152 obsolete muscular glycogenosis glycogen storage disease due to lactate dehydrogenase deficiency disorder of glycolysis