has material basis in germline mutation in RNASET2 cystic leukoencephalopathy without megalencephaly https://www.malacards.org/card/leukoencephalopathy_cystic_without_megalencephaly SCTID:720825005 GARD:0013199 MESH:C567845 MONDO:0013058 RNAse T2-deficient leukoencephalopathy CLWM Cystic leukoencephalopathy without megalencephaly is characterized by non-progressive leukoencephalopathy, bilateral cysts in the anterior part of the temporal lobe, cerebral white matter anomalies and severe psychomotor impairment. Less than 50 patients have been described in the literature so far. Inheritance is most likely autosomal recessive. MEDGEN:416646 icd11.foundation:1081165012 OMIM:612951 Orphanet:85136 UMLS:C2751843 leukoencephalopathy, cystic, without megalencephaly DOID:0081007 leukodystrophy