has material basis in germline mutation in TRMU infantile liver failure acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins https://github.com/monarch-initiative/mondo/issues/4521 https://www.malacards.org/card/liver_failure_infantile_transient Editor note: add transient course acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins MEDGEN:480294 acute infantile liver failure due to synthesis defect of mitochondrial DNA-encoded proteins Acute infantile liver failure due to mtDNA-encoded proteins synthesis defect is a very rare mitochondrial respiratory chain deficiency described in fewer than 10 infants, primarily of middle Eastern descent, and characterized clinically by transient but life-threatening liver failure with elevated liver enzymes, jaundice, vomiting, coagulopathy, hyperbilirubinemia, and lactic acidemia. liver failure, transient infantile GARD:0010593 liver failure, infantile, transient LFIT acute infantile liver failure TRMU infantile liver failure Orphanet:217371 MONDO:0013111 UMLS:C3278664 infantile liver failure caused by mutation in TRMU DOID:0080778 transient infantile liver failure OMIM:613070 mitochondrial oxidative phosphorylation disorder acute liver failure